Brief Summary
This is a Phase I dose-escalation and dose-expansion study that will evaluate the safety, pharmacokinetics (PK), and preliminary activity of GDC-6036 in patients with advancedat a late stage, far along or metastatic solid tumors with a KRAS G12C mutation.
Intervention / Treatment
- Drug: GDC-6036
- Drug: Atezolizumab
- Drug: Cetuximab
- Drug: Bevacizumab
- Drug: Erlotinib
- Drug: GDC-1971
- Drug: Inavolisib
Inclusion Criteria
- Histologically documented advanced or metastatic solid tumor with KRAS G12C mutation.
- Women of childbearing potential must agree to remain abstinent or use contraception, and agree to refrain from donating eggs during the treatment period and after the final dosethe amount of medication taken of study treatment as specified in the protocol.
- Men who are not surgically sterile must agree to remain abstinent or use a condom, and agreement to refrain from donating sperm during the treatment period and after the final dose of study treatment as specified in the protocol.