Brief Summary
Phase 1 trial to evaluate the feasibility of preparation, safety, tolerability and response to a personalised autologous tumoura tissue mass that forms from groups of unhealthy cells vaccine (ATV) formulated with Advax adjuvant when administered to patients with advancedat a late stage, far along solid cancers either as monotherapy or in combination with other standard of care agents.
Intervention / Treatment
- Biological: Radvax
Inclusion Criteria:
- Subjects must have histologically or cytologically confirmed advanced solid cancers or hematological cancers (lymphomas only)
- Subjects must have received at least one prior therapy for this disease, with the exception that subjects for whom no standard therapy options exist or who decline standard therapies can be considered for inclusion after discussions with the investigator team.
- Performance status ≤ 2 (ECOG performance status)
- Subjects or their parents if a child must have the ability to understand and the willingness to sign a written informed consenta process in which a patient receives detailed information about a procedure or treatment, including its potential risks, benefits, and alternatives. The patient then has the opportunity to understand the information and voluntarily agree to the procedure or treatment. document.
- If no suitable cancera disease where abnormal cells split without control and spread to other nearby body tissue and/or organs tissuea group of cells that work together to perform a function is already available to make the vaccine, to be enrolled in the trial participants must be willing to undergo surgerytreatment involving removal of cancerous tissue and/or tumours and a margin of healthy tissue around it to reduce recurrence and/or fresh tumour biopsyremoval of a section of tissue to analyse for cancer cells to obtain tissue to allow the preparation of the vaccine and their primary care team needs to have agreed to perform these procedures for them to obtain tumour tissue. The trial team will provide advice on appropriate tissue collection and arrange transport and processing but are not responsible for arranging such surgery or paying for its cost.